Publications by authors named "H Masuko"
Background: Allergic diseases are major causes of morbidity in both developed and developing countries and represent a global burden on health care systems. Allergic sensitization is defined as the production of IgE specific to common environmental allergens and is an important indicator in the assessment of allergic diseases.
Objective: We sought to clarify the genetic basis of allergic sensitization.
Background: Immune checkpoint inhibitor (ICI) therapy has brought about a revolutionary advance in the treatment of advanced non-small cell lung cancer (NSCLC). Not a few patients with NSCLC have comorbid diseases. In patients who already have impaired renal function, particular attention must be paid to renal toxicity, a rare immune-related adverse events.
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- The study explores the impact of adjuvant chemotherapy (UFT/LV) on disease-free survival (DFS) in high-risk stage II colon cancer patients compared to surgery alone, finding a significant DFS advantage with chemotherapy.
- In a cohort of 1902 patients, those receiving UFT/LV for six months showed a higher 5-year DFS rate compared to those who had surgery only, but overall survival (OS) rates were similar between the two groups.
- Key risk factors for poorer DFS and OS included male sex, older age (≥70 years), advanced cancer stage (T4), and lack of adjuvant chemotherapy, emphasizing the need for tailored treatment approaches in high-risk candidates.
Yellow nail syndrome (YNS) can induce bilateral exudative pleural effusion; however, to the best of our knowledge, no standard treatment for YNS has been established. The present study describes a patient with YNS for whom the pleural effusion was controlled by prednisolone. A 73-year-old man was referred to the University of Tsukuba Hospital (Ibaraki, Japan) complaining of shortness of breath, which was diagnosed as being due to bilateral pleural effusion.
View Article and Find Full Text PDFBackground: Disturbance of mucociliary clearance is an important factor in the pathogenesis of asthma. We hypothesized that common variants in genes responsible for ciliary function may contribute to the development of asthma with certain phenotypes.
Methods: Three independent adult Japanese populations (including a total of 1,158 patients with asthma and 2,203 non-asthmatic healthy participants) were studied.