Publications by authors named "H Martini"
Pertussis resurgence has been documented even in countries with high pediatric vaccine coverage. The proportion of isolates not expressing pertactin (PRN) has increased in several countries where acellular pertussis (aP) vaccines are used. We systematically reviewed published literature up to July 2023 on PRN-negative isolates in MEDLINE and Embase with no geographical limitations, complemented with a gray literature search.
View Article and Find Full Text PDFSenescent cells drive tissue dysfunction through the senescence-associated secretory phenotype (SASP). We uncovered a central role for mitochondria in the epigenetic regulation of the SASP, where mitochondrial-derived metabolites, specifically citrate and acetyl-CoA, fuel histone acetylation at SASP gene loci, promoting their expression. We identified the mitochondrial citrate carrier (SLC25A1) and ATP-citrate lyase (ACLY) as critical for this process.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied how old skin cells, called senescent cells, can make other parts of the body age faster too!
- They found that adding these old skin cells to young mice made them weaker and affected how well they could move around, as well as their thinking skills.
- This suggests that old skin cells might be spreading aging effects to other organs, like the brain, which could explain why aging can be linked to problems in both the skin and brain.
Article Synopsis
- - Senescent cells release inflammatory signals known as the senescence-associated secretory phenotype (SASP), which are linked to aging and tissue dysfunction.
- - Mitochondrial RNA (mtRNA) accumulates in these cells and activates RNA sensors, triggering the aggregation of MAVS and enhancing SASP production.
- - Targeting the RNA sensors and understanding the role of proteins like BAX and BAK can potentially reduce SASP factors and age-related inflammation, suggesting new treatment approaches for conditions like Metabolic Dysfunction Associated Steatohepatitis (MASH).
SenNet recommendations for detecting senescent cells in different tissues.
Nat Rev Mol Cell Biol
December 2024
Article Synopsis
- Cellular senescence, once thought to only occur in tissue cultures, is now recognized as playing complex roles in various biological processes across multiple species, including humans.
- Traditional understanding of senescent cells primarily comes from lab studies, but these cells are rare in actual tissues, and fully developed cells can also show signs of senescence.
- The SenNet Biomarkers Working Group has created recommendations for identifying senescent cells in tissues, analyzing literature on markers in mice and humans, and discussing new methods for detection that will assist researchers in the field.