Zinc Sensing with Pyridine-Based Lanthanide Contrast Agent: Structural Analysis in Aqueous Solution.

Zinc is an important physiological cation, and its misregulation is implicated in various diseases. It is therefore important to be able to image zinc by non-invasive methods such as Magnetic Resonance Imaging (MRI). In this work, we have successfully synthesized a novel Gd3+-based complex specifically for Zn2+ sensing by MRI.

[Targeted epigenome engineering].

Cellular differentiation and homeostasis rely on complex mechanisms to control gene expression, enabling the different cell lineages of an organism to establish and then "memorize" different epigenetic states. The processes that control gene expression are centered on chromatin, a complex of DNA, histone proteins and RNA, whose structure is finely regulated. Targeted epigenomic engineering tools make it possible to interfere with and study these processes, revealing the logic of epigenetic memory mechanisms.

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

Unlabelled: Hematological cancer treatment with hybrid kinase/HDAC inhibitors is a novel strategy to overcome the challenge of acquired resistance to drugs. We collected IC datasets from the ChEMBL database for 13 cancer cell lines (72 h cytotoxicity, measured by MTT), known inhibitors for 38 kinases, and 10 HDACs isoforms, that we identified by target fishing and literature review. The data was subjected to rigorous biological and chemical curation leaving the final datasets ranging from 76 to 8173 compounds depending on the target.

AEDEOMYIA SQUAMIPENNIS: A NEW GENUS AND SPECIES RECORD FOR COLLIER COUNTY, FLORIDA, USA.

On November 7, 2023, 3 female specimens of Aedeomyia squamipennis were captured in Collier County, Florida, for the first time during routine adult mosquito surveillance in Collier Seminole State Park. This species was first found in the USA in Miami-Dade County in 2016 and has since expanded into multiple counties throughout South Florida. The presence of Ad.

The potassium channel subunit K1.8 () is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.

In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, g, which activates negative to resting potential, confers very negative resting potentials and low input resistances, and enhances an unusual non-quantal transmission from type I cells onto their calyceal afferent terminals. Following clues pointing to K1.