Publications by authors named "H Margolis"
Amelogenin (AMELX), the predominant matrix protein in enamel formation, contains a singular phosphorylation site at Serine 16 (S16) that greatly enhances AMELX's capacity to stabilize amorphous calcium phosphate (ACP) and inhibit its transformation to apatitic enamel crystals. To explore the potential role of AMELX phosphorylation in vivo, we developed a knock-in (KI) mouse model in which AMELX phosphorylation is prevented by substituting S16 with Ala (A). As anticipated, AMELX KI mice displayed a severe phenotype characterized by weak hypoplastic enamel, absence of enamel rods, extensive ectopic calcifications, a greater rate of ACP transformation to apatitic crystals, and progressive cell pathology in enamel-forming cells (ameloblasts).
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- The study evaluates various methods used to estimate air pollution exposure specifically focusing on particulate matter and how these methods affect health outcomes relating to mortality and cardiovascular disease.
- Researchers compared annual exposure estimates assigned to participants in the Women's Health Initiative Memory Study (WHIMS) from 1999 to 2004 using different estimation techniques, including geostatistical methods and satellite data.
- Results indicated that while most approaches produced similar air pollution exposure estimates across the US, local differences were noted, and health effect associations remained consistent regardless of the estimation method used.
Pathogenic bacteria secrete protein effectors to hijack host machinery and remodel their infectious niche. spp. are obligate intracellular bacteria that can cause life-threatening disease, but their absolute dependence on the host cell environment has impeded discovery of rickettsial effectors and their host targets.
View Article and Find Full Text PDFContinuously growing mouse incisors are widely used to study amelogenesis, since all stages of this process (., secretory, transition and maturation) are present in a spatially determined sequence at any given time. To study biological changes associated with enamel formation, it is important to develop reliable methods for collecting ameloblasts, the cells that regulate enamel formation, from different stages of amelogenesis.
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- The study examined the relationship between daily air pollution levels (specifically PM2.5 and NO2) and blood pressure in over 143,000 postmenopausal women aged 50-79 from the Women's Health Initiative.
- Results indicated that short-term exposure to PM2.5 and NO2 was linked to an increase in diastolic blood pressure (DBP), with NO2 showing a stronger association overall.
- Long-term exposure to PM2.5 had a greater impact on blood pressure compared to short-term exposure, highlighting the significance of both short-term and long-term pollution effects on cardiovascular health.