The Anticancer Effect of Methanol Extract by miRNAs' Re-regulation: An Study on Human Malignant Melanoma Cells.

Alternative and natural therapies are needed for malignant melanoma (MM), the most deadly skin cancer type due to chemotherapy's limited effect. In the present study, we evaluated the anticancer potentials of methanol and water extracts (IVM and IVW) on MM cells, A2058 and MeWo, and normal fibroblasts. After the chromatographic and antioxidant activity analysis, their antiproliferative effects were determined with the increasing doses for 24-72 h.

Atmospheric pollen spectrum in Stone City, Mardin; the northern border of Mesopotamia/SE-Turkey.

Airborne pollen distribution in Mardin city was measured volumetrically during three consecutive years, 2014-2016. Three thousand eight hundred fifty-seven pollen grains as a mean value belonging to 44 taxa were recorded annually during the study period, and pollen grains from woody plant taxa had the more substantial atmospheric contribution with 62.66% and with 23 taxa.

The occurrence of Ambrosia pollen in the atmosphere of Northwest Turkey: investigation of possible source regions.

Ambrosia pollen was first reported as an important allergen in North America at the end of the nineteenth century, and many European countries have recently reported its increasing significance for pollen allergy. The aims of this study were to determine whether the highly allergenic Ambrosia pollen recorded during the studied period could be the result of long-distance transport (LDT) and to identify the potential sources of Ambrosia pollen grains. The study investigates Ambrosia pollen episodes during the peak term of six yearly periods between 2010 and 2015 by examining source regions in Ambrosia pollen in Bursa, Turkey.

Olea europaea leaf extract improves the treatment response of GBM stem cells by modulating miRNA expression.

The stem-like cells of Glioblastoma multiforme (GBM) tumors (GSCs) are one of the important determinants of recurrence and drug resistance. The aims of the current study were to evaluate the anticancer effect of Olea europaea leaf extract (OLE) on GBM cell lines, the association between OLE and TMZ responses, and the effect of OLE and the OLE-TMZ combination in GSCs and to clarify the molecular mechanism of this effect on the expression of miRNAs related to cell death. The anti-proliferative activity of OLE and the effect of the OLE-TMZ combination were tested in the T98G, U-138MG and U-87MG GBM cell lines using WST-1 assay.

Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines.

Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients is required.