Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.

Mx proteins, first identified in mammals, encode potent antiviral activity against a wide range of viruses. Mx proteins arose within the Dynamin superfamily of proteins (DSP), which mediate critical cellular processes, such as endocytosis and mitochondrial, plastid, and peroxisomal dynamics. Despite their crucial role, the evolutionary origins of Mx proteins are poorly understood.

Efficacy and safety of ivermectin-albendazole combination versus ivermectin or albendazole monotherapy in soil-transmitted helminthiasis: A systematic review and meta-analysis.

Background: Soil-transmitted helminthiasis remains a daunting challenge to global health, exerting its greatest toll on resource-limited regions of the world. A dual drug approach using the co-administration of ivermectin and albendazole has shown promising results in comparison to the traditional monotherapy strategy. In light of this, a systematic review and meta-analysis of randomized controlled trials was conducted.

Outcomes after index cholecystectomy: a UK longitudinal multi-centre cohort Study.

Purpose: International guidelines for management of acute biliary pathology recommend emergency cholecystectomy (EmC), citing improved outcomes compared to elective cholecystectomy (ElC) based on trials which may not reflect the capacity constraints in clinical practice, nor selection based on multiple prior attendances with emergency biliary pathology or attendances following a decision for ElC. We therefore conducted a longitudinal retrospective study evaluating all attendances with biliary pathology prior to cholecystectomy with the aim of assessing whether EmC is justified in this context.

Methods: Data was collected on patients undergoing cholecystectomy between 2016 and 2021 at four centres.

Insight into the Environmental Health Consciousness of Medical Students Regarding the Perceived Impacts of Climate Change on Human Health.

Climate change represents an unprecedented global public health crisis with extensive and profound implications. The Lancet Commission identified it as the foremost health challenge of the 21st century. In 2015, air pollution alone caused approximately 9 million premature deaths worldwide.

Evaluating the necessity of postoperative day 1 labs following laparoscopic radical nephrectomy (LRN).

Background: Standard postoperative care following laparoscopic radical nephrectomy (LRN) typically includes routine blood tests. Recent studies have assessed the safety of omitting routine postoperative labs in minimally invasive surgeries to reduce hospital costs. Our primary objective was to evaluate if routine postoperative day 1 (POD1) labs were necessary following LRN.