Publications by authors named "H Machado"
With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Berk. resulted in the isolation of new conjugated long-chain fatty acids (8,10,12,13)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid () and (7,8,9,11)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid () and three previously described compounds, (7,8,9)-7,8-dihydroxyoctadec-9-enoic acid (), (2)-dec-2-ene-1,10-dioic acid (), and a ketolactone marasmeno-1,15-dione ().
View Article and Find Full Text PDFBackground: Gross human anatomy is essential in undergraduate programs across biological and health sciences. While extensive literature explores medical students' knowledge in this area, studies on non-medical students, particularly those in physical education, are scarce.
Objective: This study assessed the anatomy knowledge among Brazilian physical education students and explored differences based on employment status, type of class instruction (face-to-face vs.
Prognosis and cardiotoxicity associated to adjuvant trastuzumab for breast cancer: real world study in a public health system.
Rev Bras Ginecol Obstet
December 2024
Objective: To analyze the prognosis of patients with breast cancer who developed trastuzumab-induced cardiotoxicity and to analyze factors associated with and resulting from cardiotoxicity.
Methods: This was a retrospective cohort study that included 255 HER2-positive breast cancer patients who received adjuvant trastuzumab therapy. The inclusion criteria were a diagnosis of HER2-positive breast cancer and adjuvant trastuzumab therapy; disease stage I-III; <70 years; and a baseline echocardiogram showing a left ventricular ejection fraction (LVEF) ≥ 55%.
Aim: We aim the isolated and combined effects of sedentary behaviour exposure time and physical activity levels on muscle strength in older adults.
Design: This prospective observational cohort study, analytical in nature, using exploratory survey methods and physical performance testing. With 5-year longitudinal follow-up (2015-2020).
Article Synopsis
- - The study analyzed how the Top-hat procedure affects margin status and disease relapse in women treated for high-grade squamous intraepithelial lesions (HSIL) in Brazil, involving a comparison between women who underwent the Top-hat procedure and those who did not.
- - Results showed that while a significant portion of the Top-hat group were older, the final diagnosis and relapse rates were similar between the Top-hat and non-Top-hat groups, indicating no additional benefits from the procedure.
- - A negative Top-hat result was more likely when the endocervical and ectocervical margins were negative, but ultimately, the procedure didn't change the course of treatment and should be avoided in women of reproductive