Publications by authors named "H Maalmi"
Background: Diabetic neuropathy (DN) affects up to half of individuals with type 1 and type 2 diabetes. Despite evidence that improving metabolic and cardiovascular health can slow its progression, DN remains a significant clinical challenge due to the lack of disease-modifying therapies and effective pain management strategies. This consensus aimed to identify gaps and recommend strategies to address these challenges.
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- Distal sensorimotor polyneuropathy (DSPN) is a prevalent neurological condition affecting older adults and those with obesity or diabetes, leading to significant health issues.
- The Interpretable Multimodal Machine Learning (IMML) framework was used to predict the prevalence and incidence of DSPN by analyzing a diverse set of data from over 1,000 participants, including clinical, genomic, and metabolomic information.
- Results showed that while clinical data alone could differentiate DSPN cases, combining it with additional molecular data improved prediction accuracy and identified potential biomarkers related to inflammation and fatty acid metabolism, offering new insights for treatment and prevention strategies.
Background: Diabetic sensorimotor polyneuropathy (DSPN) is often asymptomatic and remains undiagnosed. The ability of clinical and anthropometric variables to identify individuals likely to have DSPN might be limited. Here, we aimed to integrate protein biomarkers for reliably predicting present DSPN.
View Article and Find Full Text PDFBackground: The subjective experiences of individuals living with diabetes is commonly assessed with patient-reported outcomes (PROs; eg, depression symptoms, wellbeing, health-related quality of life [HRQOL], and diabetes-related distress). Cluster analyses have identified novel diabetes subtypes differing in phenotypic and metabolic characteristics. We aimed to investigate associations between these subtypes and PROs and whether subtype predicted PROs 5 years later.
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- Oxidative stress is linked to distal sensorimotor polyneuropathy (DSPN), and this study explores the role of selenoprotein P, an antioxidant protein, in individuals with and without type 2 diabetes (T2D).
- In a study with over 1,000 participants, higher levels of selenoprotein P were found to be protective against prevalent DSPN in individuals without T2D, while no such association was observed in those with T2D.
- The findings suggest that lower levels of selenoprotein P are associated with a higher prevalence of DSPN in older adults without T2D, highlighting the need for further research to understand the antioxidant properties of s