Publications by authors named "H MORIN"
Article Synopsis
- * Researchers targeted the estrogen receptor's Activation Function 2 (AF2) site using AI to identify over a billion molecules, leading to the discovery of a promising compound, VPC-260724, which inhibits estrogen receptor activity.
- * VPC-260724 was found to disrupt the interaction between the receptor and a coactivator, reducing cancer cell growth and gene expression in resistant breast cancer models, suggesting it may enhance existing therapies.
Article Synopsis
- Intra-annual variations of carbon stable isotope ratios (δ13C) in tree compartments can indicate plant carbon source-sink dynamics on a weekly basis, but tracking these variations has been challenging due to the complexity of tree ring development.
- A new method was developed to monitor weekly δ13C variability in the cambium-xylem continuum of black spruce trees over multiple growing seasons in Quebec, allowing researchers to create δ13C series for both growing cambium and developing xylem cellulose.
- Strong positive correlations between δ13C values suggest a consistent supply of fresh carbon to support tree growth, while trends in δ13C indicate potential shifts in carbon allocation strategies related to environmental factors such as seasonal light changes.
As major terrestrial carbon sinks, forests play an important role in mitigating climate change. The relationship between the seasonal uptake of carbon and its allocation to woody biomass remains poorly understood, leaving a significant gap in our capacity to predict carbon sequestration by forests. Here, we compare the intra-annual dynamics of carbon fluxes and wood formation across the Northern hemisphere, from carbon assimilation and the formation of non-structural carbon compounds to their incorporation in woody tissues.
View Article and Find Full Text PDFPurpose: Evaluation of the effectiveness of pneumatic vitreolysis in disrupting vitreomacular traction in our own cohort of patients.
Methodology: Prospective follow-up of 21 eyes of 18 patients with focal VMT (adhesion width < 1500 µm) who underwent intravitreal injection of 0.3 ml of 100% perfluoropropane between January 2015 and December 2020.
Article Synopsis
- Gene expression analysis is vital for understanding plant development, and the M2WISH protocol improves this by using microwave treatment for effective mRNA in situ hybridization in Arabidopsis.
- M2WISH allows for high-quality and uniform hybridization while preserving cellular organization, enabling detailed investigation of gene expression dynamics.
- The protocol revealed insights into how shoot apical meristems can develop from different root structures based on CLV3 expression patterns, producing valuable data for modeling complex biological systems.