[Study on the induction of chronical trichophytosis in small experimental animals for screening antimycotic agents. 3rd communication: the effect of cyclophosphamide on experimental trichophytosis in guinea pigs (author's transl)].

Elevated doses of the cytostatic cyclophosphamide (Endoxan) given daily for 6 weeks, resulted in a prolonged course of experimental trichophytosis in guinea-pigs. From this phenomenon, it may be concluded that the short self-healing course of this disease is due to a rapid triggering of immunoreactions. The fractionated treatment with cyclophosphamide at defined intervals (50 mg/kg initially and 30 mg/kg at 4-day intervals) did not result in any effect.