Publications by authors named "H MARQUEZ"
Toxin-antidote elements (TAs) are selfish DNA sequences that bias their transmission to the next generation. TAs typically consist of two linked genes: a toxin and an antidote. The toxin kills progeny that do not inherit the TA, while the antidote counteracts the toxin in progeny that inherit the TA.
View Article and Find Full Text PDFArticle Synopsis
- Researchers created a mouse induced pluripotent stem cell (iPSC) line that can specifically produce lung mesenchyme, which is crucial for lung development and disease.
- They identified specific pathways (RA and Shh) that are necessary for differentiating these iPSCs into lung mesenchyme, which exhibits similar features to primary lung mesenchyme.
- These iPSC-derived lung mesenchymal cells can organize into 3D structures with lung epithelial progenitors, demonstrating their potential for studying lung development, modeling diseases, and developing new treatments.
Background: A progressive volitional cycling test is useful in determining exercise prescription in populations with cardiovascular and metabolic diseases. However, little is known about the association between heart rate during this test and endothelial dysfunction (EDys) parameters in hypertensive (HTN) patients.
Objective: To investigate the association between EDys markers (flow-mediated dilation [FMD], pulse wave velocity of the brachial artery [PWVba], and carotid-intima media thickness [cIMT]) and heart rate during a cycling test in HTN adults.
Identification of the genetic basis of phenotypic variation within species remains challenging. In species with low recombination rates, such as , genomic regions linked to a phenotype of interest by genetic mapping studies are often large, making it difficult to identify the specific genes and DNA sequence variants that underlie phenotypic differences. Here, we introduce a method that enables researchers to induce heritable targeted recombination in with Cas9.
View Article and Find Full Text PDFIdentification of the genetic basis of phenotypic variation within species remains challenging. In species with low recombination rates, such as , genomic regions linked to a phenotype of interest by genetic mapping studies are often large, making it difficult to identify the specific genes and DNA sequence variants that underlie phenotypic differences. Here, we introduce a method that enables researchers to induce targeted recombination in with Cas9.
View Article and Find Full Text PDF