Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling.

Adjuvants are a diverse group of substances that can be added to vaccines to enhance antigen-specific immune responses and improve vaccine efficacy. The first adjuvants, discovered almost a century ago, were soluble crystals of aluminium salts. Over the following decades, oil emulsions, vesicles, oligodeoxynucleotides, viral capsids, and other complex organic structures have been shown to have adjuvant potential.

A low cost and labor-efficient method for rearing an invasive beetle, Carpophilus truncatus (Coleoptera: Nitidulidae).

The carpophilus beetle, Carpophilus truncatus Murray, 1864 (Coleoptera: Nitidulidae) is an invasive pest recently detected in California's tree nut crop orchards. Here we report a simple, labor-saving, and cost-effective rearing system for C. truncatus utilizing banana and industrial sand components.

Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages.

The role of myeloid cells in the pathogenesis of SARS-CoV-2 is well established, in particular as drivers of cytokine production and systemic inflammation characteristic of severe COVID-19. However, the potential for myeloid cells to act as bona fide targets of productive SARS-CoV-2 infection, and the specifics of entry, remain unclear. Using a panel of anti-SARS-CoV-2 monoclonal antibodies (mAbs) we performed a detailed assessment of antibody-mediated infection of monocytes/macrophages.