Basic Science and Pathogenesis.

Background: NIAGADS is a national genomics data repository that facilitates access of genotypic and sequencing data to qualified investigators for the study of the genetics of Alzheimer's disease (AD) and related neurological diseases. Collaborations with large consortia and centers such as the Alzheimer's Disease Genetics Consortium (ADGC), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Alzheimer's Disease Sequencing Project (ADSP), and the Genome Center for Alzheimer's Disease (GCAD) allow NIAGADS to lead the effort in managing large AD datasets that can be easily accessed and fully utilized by the research community.

Method: NIAGADS is supported by the National Institute on Aging (NIA) under a cooperative agreement.

Basic Science and Pathogenesis.

Background: NIAGADS is a national data repository that offers qualified investigators access to genomic data for Alzheimer's disease (AD) and related dementia. In addition, NIAGADS has made substantial effort to curate, harmonize, standardize, and disseminate AD-relevant variant, gene, and sequence annotations from publications, functional genomics datasets, and summary statistics deposited at NIAGADS. These results are made available to the public in a collection of interactive knowledgebases (AD Variant Portal, FILER Functional Genomics Repository, VariXam, Alzheimer's GenomicsDB & Genome Browser), all of which are accessible programmatically via the NIAGADS API.

The sexual and reproductive health needs and preferences of youths in sub-Saharan Africa: A meta-synthesis.

The sexual and reproductive health (SRH) needs of youths in sub-Saharan Africa are not being fully met, as evidenced by high rates of unintended pregnancies and sexually transmitted infections in this population. Understanding service needs and preferences of sub-Saharan African youths aged 10-24 years is critical for improving access and SRH outcomes and the focus of this systematic review of qualitative research. Four databases were searched with key words to identify relevant studies, supplemented by citation search, with an update in June 2023.

Meta-epidemiology and reporting characteristics of mapping reviews: a scoping review.

Objectives: To investigate the meta-epidemiology and reporting characteristics of mapping reviews.

Study Design And Setting: We conducted a scoping review of a sample of recent mapping reviews (2022-2023) by searching nine electronic databases and eleven institutional websites up to January 2024. A 28-item reporting checklist, developed by our team and based on existing guidance and methodological studies of mapping reviews, was employed to assess reporting characteristics.