Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease.

Background: The inflammatory macrophage response contributes to severe Ebola virus disease, with liver and lung injury in humans.

Objective: We sought to further define the activation status of hepatic and pulmonary macrophage populations in Ebola virus disease.

Methods: We compared liver and lung tissue from terminal Ebola virus (EBOV)-infected and uninfected control cynomolgus macaques challenged via the conjunctival route.

Precision in Immune Management: Balancing Steroid Exposure, Rejection Risk, and Infectious Outcomes in Adult Kidney Transplant Recipients.

Background/objectives: With kidney transplant immunosuppression, physicians must balance preventing rejection with minimizing infection and malignancy risks. Steroids have been a mainstay of these immunosuppression regimens since the early days of kidney transplantation, yet their risks remain debated. Our study looks at the clinical outcomes of patients undergoing early steroid withdrawal (ESW) vs.

A Comparison of Delivery Modalities for Pregnancy Clinical Care Management: Telephonic Versus Video.

Objective: Given the high prevalence of maternal morbidity and mortality, it is imperative that maternal health interventions are comprehensively evaluated, so they can be scaled with fidelity. Community-based care management models focused on perinatal health care are a priority for health care systems and payers. Alternative care management delivery modalities, such as video visits, are needed to expand program reach amidst growing system-level challenges.

Network analysis of ethnic-racial socialization competency and content among diverse parents of color: An eye toward intervention targets.

To help their children survive and thrive in our unequal society, parents of color must engage in the process of ethnic-racial socialization (ERS) or teaching about race, ethnicity, and racism. Equally important to the provision of ERS messages are parents' confidence, skills, and stress levels around delivering ERS (i.e.