An Improved Impact Ratio for Identifying Critical Process Parameters in Pharmaceutical Manufacturing Processes.

The identification of critical process parameters in biologics and small molecule process development is a key element of quality by design. The objectivity and consistency of procedures to identify critical process parameters can be improved with the use of impact ratios. Impact ratios quantify a process parameter's practical effect on a critical quality attribute relative to the critical quality attribute's acceptance limits.

Synthesis, structure, and dynamic behavior of cyclopentadienyl-lithium, -sodium, and -potassium annelated with bicyclo[2.2.2]octene units: a systematic study on site exchange of alkali metals on a cyclopentadienyl ring in tetrahydrofuran.

Novel cyclopentadienyl (Cp)-alkali metal complexes 1-M and 2-M (M = Li, Na, K), in which the Cp ring is annelated with two bicyclo[2.2.2]octene units and substituted with a phenyl group for 1 and a tert-butyl group for 2, were synthesized, and their structures and dynamic behaviors were investigated by means of X-ray crystallography, dynamic (13)C NMR, and DFT calculations.

Cleanup of gloves contaminated with granular terbufos and tefluthrin.

Chemical-resistant gloves are used for protection from pesticides in farming operations. Cleanup of gloves after pesticide contamination was the focus of this research. Nitrile, neoprene, and barrier laminate glove specimens were exposed to 300 mg terbufos or tefluthrin granules for 3 or 30 min in petri dishes in a laboratory.

Effects of exposure time, material type, and granular pesticide on glove contamination.

Chemical-resistant gloves are recommended for pesticide applicators to reduce their exposure to agricultural chemicals. In this research, three chemical-resistant glove materials-nitrile, neoprene, and barrier laminate-were studied in relation to contamination with granular terbufos and tefluthrin. Surfaces of specimens backed with alpha cellulose were contaminated with 300 mg of either granular terbufos or tefluthrin for 1-, 2-, 4-, 8-, 16-, and 24-h time periods in petri dishes in the laboratory.