Publications by authors named "H M Ruetten"
Prostate fibrosis contributes to lower urinary tract dysfunction (LUTD). To develop targeted treatments for prostate fibrosis, it is necessary to identify cell types and molecular pathways required for collagen production. We used a genetic approach to label and track potential collagen-producing cell lineages in mouse prostate through a round of Escherichia coli (E.
View Article and Find Full Text PDFLocal tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model.
Am J Physiol Gastrointest Liver Physiol
January 2025
This study aimed to determine if local injection of CXCL12 reduces sphincter fibrosis, restores sphincter muscle content, vascularization, and innervation, and recruits progenitor cells in a rabbit model of anal sphincter injury and incontinence. Adult female rabbits were assigned to 3 groups: uninjured/no treatment (control), injured/treated (treated), and injured/no treatment (untreated) (n=4 each). Injured groups were anesthetized and a section of external anal sphincter was removed at the 9:00 o'clock position.
View Article and Find Full Text PDFArticle Synopsis
- Researchers are studying type 2 diabetes, which happens when there is too much sugar in the blood, to see how certain substances in the body, called metabolites, are connected to it.
- They looked at 3,000 blood samples and analyzed 911 metabolites to find out how these substances relate to blood sugar levels.
- They discovered several metabolites that are different in people with normal blood sugar, those with prediabetes, and those with type 2 diabetes, mainly focusing on specific amino acids and fats.
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood.
Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.
Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.
Article Synopsis
- The study examines genetic regulation of mRNA, proteins, and metabolites in blood samples from over 3,000 people, revealing that many genetic variants influence multiple molecular traits.* -
- It finds that there's a strong genetic connection between gene expression and protein levels (66.6%), and shows broad connections across various tissues, highlighting the shared genetic basis for different traits.* -
- By creating networks of known genetic variants, the research indicates that these variants are more frequently linked to gene expression rather than other molecular traits, helping to clarify the mechanisms behind genetic associations.*