TSPO-PET and diffusion-weighted MRI for imaging a mouse model of infiltrative human glioma.

Background: Glioblastoma (GBM) is the most devastating brain tumor. Despite the use of multimodal treatments, most patients relapse, often due to the highly invasive nature of gliomas. However, the detection of glioma infiltration remains challenging.

Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake.

The tumor microenvironment is highly heterogeneous. For gliomas, the tumor-associated inflammatory response is pivotal to support growth and invasion. Factors of glioma growth, inflammation, and invasion, such as the translocator protein (TSPO) and matrix metalloproteinases (MMP), may serve as specific imaging biomarkers of the glioma microenvironment.

Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions.

We have isolated the high-M(r) mucins from growth medium of the early stage of an HT-29 cell culture by gel chromatography and isopycnic density gradient centrifugation. The mucins (buoyant density 1.34-1.

Nurses' perceptions of pain in the neonatal intensive care unit.

Pain in neonates has only recently become the focus of clinical and research attention. Measurement of pain in this population presents special problems. Neonatal nurses were selected as observers and recorders of neonatal pain behavior, as they are in constant contact with neonates undergoing aversive procedures, and thus have special expertise in this area.