Quantitative analysis of heparan sulfate using isotopically labeled calibrants.

Heparan sulfate is a sulfated polysaccharide that displays essential physiological functions. Here, we report a LC-MS/MS-based method for quantitatively determining the individual disaccharide composition and total amount of heparan sulfate. Using eight C-labeled disaccharide calibrants and one C-labeled polysaccharide calibrant, we complete the analysis in one-pot process.

Drug companies and clinical psychology.

This article argues that the pharmaceutical industry uses psychological techniques focusing on social conditioning, shame, and guilt to sell its concepts and products to an ever-widening group of health care professionals. Clinical psychology shows signs of both joining and resisting this process.

The use of diagnostic sleep nasendoscopy in the management of children with complex upper airway obstruction.

In this paper we present a prospective study of the role of diagnostic sleep nasendoscopy in the investigation and treatment of 20 children referred to a tertiary children's hospital with obstructive awake apnoea or severe obstructive sleep apnoea (apnoea/hypopnoea index greater than 30/h). We describe the technique of diagnostic sleep nasendoscopy and provide a classification system for documenting the findings. We demonstrate sleep nasendoscopy is an invaluable tool in the management of children who continue to have upper airway obstruction despite previous adenotonsillectomy and in children with airway obstruction due to cerebral palsy, syndromes and craniofacial malformations.

Lymphangioma of the tongue presenting as Ludwig's angina.

In this paper we present a case of a 6-year-old child who presented with Ludwig's angina caused by an infected tongue base lymphangioma. We provide a literature review of tongue lymphangioma and Ludwig's angina in the paediatric population. Both Ludwig's angina and tongue base lymphangioma are rare conditions in their own right and a combination of the two has not previously been described in the literature.