Publications by authors named "H M McGuire"

Article Synopsis
  • The study explores the role of inflammatory cytokines and receptors—specifically TRAIL, IL-18, and OPG—in predicting atherosclerotic coronary artery disease (CAD), especially when traditional risk factors are absent.
  • It involved analyzing serum biomarker levels from 993 participants to see how these markers correlated with the severity of CAD as determined by CT scans.
  • Although some associations were found between these inflammatory markers and CAD scores, they did not remain significant when adjusted for other risk factors like age, sex, and family history, indicating they may not be reliable standalone predictors of CAD.
View Article and Find Full Text PDF

Postgraduate fellowship training for nurse practitioners (NP) in palliative care can ameliorate workforce shortages; however, currently there are few NP fellowships and little evidence about outcomes, such as retention in hospice and palliative nursing, job satisfaction, or professional contributions. To describe the impact of palliative care fellowship training on the careers of NP alumni. A survey was electronically distributed to all NP alumni of an interprofessional palliative care fellowship since adult and pediatric nursing cohorts were added (2009-2022).

View Article and Find Full Text PDF

Approximately 50% of melanoma patients fail to respond to immune checkpoint blockade (ICB), and acquired resistance hampers long-term survival in about half of initially responding patients. Whether targeting BET reader proteins, implicated in epigenetic dysregulation, can enhance ICB response rates and durability, remains to be determined. Here we show elevated BET proteins correlate with poor survival and ICB responses in melanoma patients.

View Article and Find Full Text PDF

Access to supportive services in community-based oncology is challenging but essential, particularly for underserved populations. We developed the Supportive Oncology Collaborative (SOC), built upon the tenets of Collaborative Care, an existing model used to increase access to behavioral health in community settings. Using a population-health-based approach with screening, a registry, and shared care, we added palliative care specialists to a team of social workers and a consulting psychiatrist.

View Article and Find Full Text PDF

Despite the high rates of firearm ownership and firearm-related injuries and mortalities in Southern US states, understandings on the factors contributing to these are lacking. Using wave 10 (2021) data from a longitudinal study, we examined firearm-related experiences among 636 ethnically diverse young adults (mean age=26 years; 62% female) in Texas, USA. Just over half of participants had ready access to firearms, with 22.

View Article and Find Full Text PDF