Publications by authors named "H M M van Beusekom"
Background: The MR CLEAN NO-IV trial showed neither superiority nor noninferiority of endovascular treatment (EVT) alone compared to intravenous thrombolysis (IVT; Alteplase) before EVT in acute ischemic stroke (AIS) patients with large vessel occlusion of the anterior circulation. Although the treatment effect is largely attributable to EVT, IVT may affect hypercoagulability during AIS.
Aims: To investigate the association between activated coagulation and final infarct volume and clinical outcomes (modified Rankin Scale 3-6 and mortality 90 days post-EVT), and whether this effect is modified by IVT administration.
Article Synopsis
- - The study investigated the occurrence of thoracic aortic aneurysms (TAA) in relatives of patients with abdominal aortic aneurysms (AAA), even when they had no known genetic risks for aneurysms.
- - Researchers conducted noncontrast CT scans on 301 relatives of 115 AAA patients, revealing a significant increase in TAA and thoracic dilatations compared to the general population.
- - The findings suggest there may be unknown genetic factors contributing to aneurysm risk in families, highlighting the need for whole aorta imaging of relatives of all AAA patients for better detection and management.
Article Synopsis
- - The study investigates how red blood cell (RBC) and platelet content in blood clots affect CT imaging characteristics and mechanical properties, which could help predict the success of thrombectomy procedures.
- - Researchers created blood clot analogues with varying RBC and platelet concentrations and used imaging techniques (NCCT and CECT) to assess clot densities and mechanical properties under stress.
- - Findings suggest that while RBC content primarily determines non-contrast CT density, platelet content significantly impacts contrast-enhanced density and clot stiffness, indicating both components play unique roles in clot characteristics.
Article Synopsis
- Aortic aneurysms (AA) often happen because of problems with a protein called TGF-β, and researchers were looking at a gene called FURIN that helps process this protein.
- They found rare changes in the FURIN gene in some patients with aortic aneurysms, and these changes were linked to more serious health issues.
- The study suggests that FURIN is an important gene that can increase the chances of having different types of aortic aneurysms, and how it affects people can vary based on their unique genetics.