Publications by authors named "H M Kuerer"
Purpose: The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management is not standardized. We investigated rates of additional positive lymph nodes (LNs) at axillary lymph node dissection (ALND) and oncologic outcomes in patients with ypN0i+ treated with and without ALND.
Methods: The Oncoplastic Breast Consortium-05/ICARO cohort study (ClinicalTrials.
Article Synopsis
- This study investigated factors linked to positive sentinel lymph nodes (SLNs) in cT1-2N0 breast cancer patients who received neoadjuvant chemotherapy (NACT) and how this data might differ from patients who didn't receive NACT.
- Out of 1,930 patients studied, 12.1% had positive SLNs, with specific tumor characteristics (like hormone receptor-positive status and lobular histology) significantly predicting this outcome.
- The findings suggested low axillary recurrence rates in patients with positive SLNs, indicating that certain tumor features and older age could help identify individuals at higher risk for further disease after treatment.
Article Synopsis
- The study examines the effectiveness of targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC) in breast cancer patients, focusing on the status of clipped nodes during axillary staging.
- Out of 680 patients analyzed, 90% had their clipped nodes identified as sentinel lymph nodes (SLN), while 10% were classified as non-SLN, with a significant proportion (60%) of non-SLNs showing metastasis.
- The findings suggest that when the clipped node is a non-SLN, it often serves as the sole positive node, highlighting the importance of clipping for accurate residual disease assessment and better informing adjuvant therapy decisions.