Biomarkers.

Background: Stronger default mode (DMN) and bilateral frontoparietal control network (FPCN) resting-state functional connectivity are associated with reduced β-amyloid (Aβ)-related cognitive decline in cognitively unimpaired older adults, who were predominantly Aβ negative. This suggests that these networks might support cognitive resilience in the face of early AD pathology but it remains unclear whether these effects are apparent in preclinical AD. We investigated whether left-FPCN, right-FPCN, and DMN connectivity moderated the effect of Aβ on cognitive decline using a large multi-site dataset from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) study.

Developing Topics.

Background: Older women have a higher prevalence of Alzheimer's disease relative to comparably aged men. Although the biological mechanisms driving this sex difference remain elusive, emerging data suggest that longevity, APOEε4, inflammation, and blood glucose levels may play roles. Our objective was to examine the associations of APOEε4, high sensitivity-C-reactive protein (hs-CRP), and fasting blood glucose levels with cognitive changes over time among women enrolled in two ancillary studies of the Women's Health Initiative (WHI).

Developing Topics.

Background: Hormone therapy (HT) is often used to manage symptoms related to menopause, but its longer-term effects on depressive symptoms in older women remains unclear. Previous literature reports inconclusive results on whether HT use is protective against or associated with increased depressive symptoms over time in older women. The objective of this study was to examine the associations of self-reported HT use with baseline and longitudinal later life depressive symptoms.

Developing Topics.

Background: The residual approach has found wide application in researching cognitive resilience, a phenomenon conceptually understood as cognitive performance being better-than-typical for an individual, despite apparent AD pathology. The standard residual approach extracts information about an individual's resilience from the residuals of a linear model predicting cognition. This approach is subject to several limiting assumptions.

Alzheimer's Imaging Consortium.

Background: Stronger default mode (DMN) and bilateral frontoparietal control network (FPCN) resting-state functional connectivity are associated with reduced ß-amyloid (Aß)-related cognitive decline in cognitively unimpaired older adults, who were predominantly Aß negative. This suggests that these networks might support cognitive resilience in the face of early AD pathology but it remains unclear whether these effects are apparent in preclinical AD. We investigated whether left-FPCN, right-FPCN, and DMN connectivity moderated the effect of Aß on cognitive decline using a large multi-site dataset from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) study.