Control of Reversible Oxidative Addition/Reductive Elimination of Surface-Attached Catalysts by External Electric Fields.

We demonstrate that applied electric fields at interfaces can control the oxidative addition/reductive elimination equilibria of surface-attached molecular catalysts without any synthetic modification. Density functional theory (DFT) calculations show that the oxidative addition of HCl to a Co complex is "field switchable", being favorable under negative fields but unfavorable under sufficiently positive fields. Extending the analysis to different substrates (O, H) and metal centers (Rh, Ir) reveals consistent trends in the magnitude of the electric field effect: Co > Rh ≈ Ir and HCl > O > H.

The role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers - A literature review.

Diabetic Foot Ulcers (DFUs) are chronic foot wounds, in a person with diabetes, which are associated with peripheral arterial insufficiency and/or peripheral neuropathy of the lower limb. Recent UK audit figures report that approximately 50-60 % of DFUs remain unhealed after 12 weeks. Previous research has suggested that ischaemia plays a key role in the pathophysiology of many chronic wounds, including DFUs.

CAR+ T-Cell Lymphoma after Cilta-cel Therapy for Relapsed or Refractory Myeloma.

We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel (cilta-cel) in the phase 3 CARTITUDE-4 trial. Monoclonal T cells from both patients had detectable CAR transgene expression and integration. The clinicogenomic features of these CAR transgenic T-cell lymphoproliferative neoplasms suggest that multiple potential intrinsic or extrinsic factors (or both) contributed to their pathogenesis, such as transduction of preexisting -mutated T cells, followed by acquisition of further oncogenic genomic variants.

The Diverse Pathways for Cell Surface MT1-MMP Localization in Migratory Cells.

Controlled cell migration is an essential biological process in health, while uncontrolled cell migration contributes to disease progression. For cells to migrate through tissue, they must first degrade the extracellular matrix (ECM), which acts as a physical barrier to cell migration. A type I transmembrane-type matrix metalloproteinase, MT1-MMP, is the key enzyme involved in this process.

Medical student experiences of Case-Based Learning (CBL) at a multicultural medical school.

Background: Educational research highlights active approaches to learning are more effective in knowledge retention and problem-solving. It has long been acknowledged that adapting to more active ways of learning form part of the challenge for new university students as the pedagogical distance between the didactical approach largely followed by secondary school systems the world over differs quite significantly from the often more student-led, critical approach taken by universities. University students encounter various learning challenges, particularly during the transition from secondary school to university.