Invasive ductal carcinoma of the breast with osteoclast-like giant cells and clear cell features: a case report of a novel finding and review of the literature.

Background: Osteoclast-like giant cells (OLGCs) are a rare histologic finding within a tumor of the breast. Although there has been discussion as to the pathogenesis and prognosis related to this finding, our understanding of its significance remains inconclusive. Clear cells are another unique histologic finding in breast tumors and are typically associated with tumors arising in other organs such as renal cell carcinoma.

Mini-intervention for subacute low back pain: a randomized controlled trial.

Study Design: Randomized controlled trial.

Objectives: To investigate the effectiveness and costs of a mini-intervention, provided in addition to the usual care, and the incremental effect of a work site visit for patients with subacute disabling low back pain.

Summary Of Background Data: There is lack of data on cost-effectiveness of brief interventions for patients with prolonged low back pain.

The search for level I evidence in solid-tumor oncology.

Background: We have developed a method to identify, filter, review, and distribute the published level I evidence for solid tumor oncology.

Methods: A standardized MEDLINE search identified prospective randomized controlled trials (PRCTs) in solid tumor oncology. Only PRCTs with therapeutic end points were included.

Soft tissue tumors of the abdominal wall: analysis of disease patterns and treatment.

Hypothesis: Abdominal wall tumors, though clinically similar, have varying degrees of biological behavior.

Design: Retrospective review of prospective databases.

Setting: Memorial Sloan-Kettering Cancer Center.

Results of total pancreatectomy for adenocarcinoma of the pancreas.

Hypothesis: Total pancreatectomy for infiltrating ductal adenocarcinoma is not superior to pancreaticoduodenectomy or distal pancreatectomy.

Design: A retrospective analysis of a prospective database of patients.

Setting: Memorial Sloan-Kettering Cancer Center, New York, NY.