Recent advances in fucoidan-based improved delivery systems: Structure, carrier types and biomedical applications.

Consumer demand for nutritional supplements has fueled the rapid growth of the functional food market. However, ensuring the stability of functional factors in harsh environments remains a major challenge. The development of encapsulation systems is regarded as an effective method for enhancing the stability of functional factors, encapsulation carriers can offer protection for these functional factors.

Production, structure, and performance of guar gum based bacterial cellulose generated from soy sauce residue hydrolysate by in-situ fermentation.

Guar gum based bacterial cellulose (GG-BC) was generated from the soy sauce residue hydrolysate by in-situ fermentation, and its structure and performance were learned systematically. The GG concentration of 0.2 % was most suitable for GG-BC production with the yield of 1.

A conformational switch-controlled RNA sensor based on orthogonal dCas12a for RNA imaging in live cells.

RNA imaging technology is essential for understanding the complex RNA regulatory mechanisms and serves as a powerful tool for disease diagnosis. However, conventional RNA imaging methods often require multiple fluorescent tags for the specific labeling of individual targets, complicating both the imaging process and subsequent analysis. Herein, we develop an RNA sensor that integrates a blocked CRISPR RNA (crRNA)-based conformational switch with a controllable CRISPR activation (CRISPRa) system and apply for RNA imaging.

Assessment of four sterilization techniques for meniscal allograft transplantation in rabbits.

Purpose: This study aimed to compare the effects of four sterilization techniques on meniscal allograft transplantation (MAT) in rabbits.

Methods: In total, 85 medial or lateral meniscuses were obtained from 22 adult New Zealand white rabbits. These 85 meniscal allografts were seeded with () and randomly divided into five groups (= 17): iodine group, Cobalt-60 group, glutaraldehyde group, ethylene oxide group and control group.

New insight in immunotherapy and combine therapy in colorectal cancer.

The advent of immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC) treatment marks a major breakthrough. These therapies have proven safer and more effective than traditional radiotherapy and targeted treatments. Immunotherapies like pembrolizumab, nivolumab, and ipilimumab have pioneered new treatment avenues, potentially improving patient outcomes and quality of life.