Publications by authors named "H M Hashem"

Inborn errors of immunity (IEI) are a heterogenous group of rare monogenic disorders that affect innate or adaptive immunity, resulting in susceptibility to life-threatening infections and autoimmunity. Allogeneic hematopoietic cell transplantation (HCT) is a valuable curative option for children with IEI. We conducted a retrospective single-center study on the outcome of HCT in children with IEI.

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Unlabelled: The demand for energy resources is constantly increasing. That means need more fossil fuels to provide them. People consume a lot of food and this produces many wastes.

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Article Synopsis
  • The study investigates a new ciprofloxacin-chalcone hybrid (CP derivative) for its potential anticancer effects as inhibitors of Topoisomerases I and II.
  • In vitro tests demonstrate that the CP derivative significantly reduces the growth of cancer cells, outperforming the standard drug Staurosporine.
  • The compound induces apoptosis and cell cycle arrest, and shows effective inhibition of Topo I and II enzymes, suggesting its potential as a new anticancer therapy.
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Article Synopsis
  • The study focused on antimicrobial resistance in carbapenem-resistant clinical isolates and their ability to produce biofilms and various resistance enzymes.
  • About 50% of the isolates were multidrug-resistant, with 98.4% producing extended-spectrum β-lactamases and significant levels of biofilm production.
  • The presence of multiple resistance genes was common, indicating a high prevalence of antimicrobial resistance mechanisms, which may contribute to the emergence of multidrug-resistant phenotypes.
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Commonly used antimicrobial agents are no longer effective due to their overuse or misuse. In addition, many medicinal plant extracts can combat infectious diseases due to their main active constituents or secondary metabolites. The current study aimed to assess the bioactivities of (LN) leaf extract (LE) against different multi-drug resistant (MDR) () isolates.

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