Publications by authors named "H M El Tayebi"
Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity compartments to play several roles in tumour progression. Tumour-associated macrophages (TAMs), one of the most dominant components in the tumour microenvironment, are recognized as anti-tumour suppressors.
View Article and Find Full Text PDFBackground: An individual's genetic fingerprint is emerging as a pivotal predictor of numerous disease- and treatment-related factors. Single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes play key roles in an individual's exposure to a malignancy-associated risk, such as Aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC).
Aim: This study aimed at reviewing literature on the polymorphisms that exist in CYP enzymes and their possible link with susceptibility to AFB1-induced HCC.
Article Synopsis
- Multiple sclerosis (MS) is a chronic condition characterized by the deterioration of nerve insulation, and the study aimed to assess the effectiveness of metformin combined with interferon beta 1a in patients with relapsing-remitting MS.
- Eighty patients were divided into two groups: one received metformin with IFNβ-1a, while the other only received IFNβ-1a. After six months, no significant differences were found between the two groups in several measured outcomes, including inflammatory markers and disability status.
- Although the addition of metformin showed a potential effect on reducing levels of an oxidative stress marker (MDA), the overall immunological and clinical outcomes did not demonstrate significant