Publications by authors named "H M David"
HIV pre-exposure prophylaxis (PrEP) is a cornerstone of the Ending the HIV Epidemic plan. We evaluated sociodemographic factors associated with PrEP use in jurisdictions with high HIV diagnosis rates between the initial years of PrEP rollout in the U.S.
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- * The p.Ala1035Val variant is the most common in Portugal and is linked to a potential SNP (p.Ile858Val) that may affect disease progression.
- * Research using in vitro models reveals that the p.Ala1035Val variant, especially when combined with p.Ile858Val, shows decreased lysosomal trafficking similar to p.Ile1061Thr, suggesting the need for new therapeutic approaches.
Neonatal hypoxic-ischemic encephalopathy (HIE) represents a significant global disease burden, but more importantly, it leaves a lasting impact of disability on individual children and their families. HIE outcome prognostication is important for guiding clinical interventions and counseling families. The objective of this study was to systematically review early electroencephalogram (EEG) and magnetic resonance imaging (MRI) features associated with long-term neurological outcomes in infants after perinatal HIE.
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- The study explores the impact of COVID-19 on maternal deaths in Brazil, utilizing data from national health databases to predict maternal mortality ratios for 2020 and 2021 based on historical data.
- In 2021, the actual comprehensive maternal mortality ratio (MMRc) was over double what was predicted, highlighting significant increases in maternal deaths during this period.
- There were notable regional differences in maternal mortality, with the South experiencing the highest rates, and the report suggests that enhancing prenatal and postpartum care is essential to address the rising trend in comprehensive maternal deaths.
Aptamers: precision tools for diagnosing and treating infectious diseases.
Front Cell Infect Microbiol
October 2024
Article Synopsis
- * Traditional diagnostic methods are complex and time-consuming, highlighting the need for faster and more accurate approaches, which aptamer-based technologies can provide due to their cost-effectiveness, sensitivity, and specificity.
- * Aptamers, which are RNA or DNA sequences similar to monoclonal antibodies, have diverse applications in biomedicine for diagnostics, treatment, and imaging, and this review emphasizes their role in tackling infectious diseases.