Publications by authors named "H M A Hofstee"
Background: The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) with compression ultrasonography (CUS) may be hindered by residual intravascular obstruction after previous DVT. A reference CUS, an additional ultrasound performed at anticoagulant discontinuation, may improve the diagnostic work-up of suspected recurrent ipsilateral DVT by providing baseline images for future comparison.
Objectives: To evaluate the cost-effectiveness of routinely performing reference CUS in DVT patients.
Background: The recently published 4-level Pulmonary Embolism Clinical Probability Score (4PEPS) integrates different aspects from currently available diagnostic strategies to further reduce imaging testing in patients with clinically suspected pulmonary embolism (PE).
Aim: To externally validate the performance of 4PEPS in an independent cohort.
Methods: In this post-hoc analysis of the prospective diagnostic management YEARS study, the primary outcome measures were discrimination, calibration, efficiency (proportion of imaging tests potentially avoided), and failure rate (venous thromboembolism (VTE) diagnosis at baseline or follow-up in patients with a negative 4PEPS algorithm).
Article Synopsis
- The SHARP study aimed to gather real-world evidence on severe asthma treatment by linking data from 10 different national registries across Europe, focusing on patients treated with mepolizumab.
- The analysis, which included 912 patients, found that mepolizumab significantly reduced the frequency of asthma exacerbations and the use of maintenance oral glucocorticoids before and during the COVID-19 pandemic.
- The study highlighted considerable variation in patient characteristics and treatment practices between the different registries, emphasizing the diverse nature of severe asthma management in Europe.
Article Synopsis
- This study looked at how to safely check if pregnant women might have a serious condition called pulmonary embolism (PE) using different tests and rules.
- They found that using the Wells rule and certain blood tests (D-dimer) can help figure out if PE is likely, and these methods worked well without too many false alarms.
- However, another test using ultrasound on veins (CUS) didn’t work well unless the patients had more obvious symptoms of another condition, so it's better to use the blood tests in these cases.
Article Synopsis
- The Pulmonary Embolism Severity Index (PESI) and its simplified version (sPESI) are used to predict mortality in pulmonary embolism patients, while the National Early Warning Score (NEWS) serves as a general risk score in various clinical situations.
- A study of 352 haemodynamically stable PE patients assessed the effectiveness of the NEWS, PESI, and sPESI in predicting both ICU admissions and 30-day mortality through receiver operating characteristic analysis.
- Results indicated that the NEWS outperformed PESI and sPESI in predicting ICU admissions and had a high accuracy for 30-day mortality, suggesting that NEWS may be a valuable tool in clinical settings for managing patients with pulmonary embolism.