Discovery of megapolipeptins by genome mining of a bacteria collection.

bacteria have emerged as a promising source of structurally diverse natural products that are expected to play important ecological and industrial roles. This order ranks in the top three in terms of predicted natural product diversity from available genomes, warranting further genome sequencing efforts. However, a major hurdle in obtaining the predicted products is that biosynthetic genes are often 'silent' or poorly expressed.

Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a bacterium.

Bacterial natural products have found many important industrial applications. Yet traditional discovery pipelines often prioritize individual natural product families despite the presence of multiple natural product biosynthetic gene clusters in each bacterial genome. Systematic characterization of talented strains is a means to expand the known natural product space.

Tolypocaibols: Antibacterial Lipopeptaibols from a sp. Endophyte of the Marine Macroalga .

Two new lipopeptaibols, tolypocaibols A () and B (), and the mixed NRPS-polyketide-shikimate natural product maximiscin [(/)-)] were isolated from a sp. fungal endophyte of the marine alga . Analysis of NMR and mass spectrometry data revealed the amino acid sequences of the lipopeptaibols, which both comprise 11 residues with a valinol C-terminus and a decanoyl acyl chain at the N-terminus.