Publications by authors named "H Lyytinen"
Purpose: This study aimed to analyze changes in serum estradiol (E2) levels during concurrent vaginal estradiol therapy and adjuvant letrozole in postmenopausal breast cancer (BC) patients with vulvovaginal atrophy (VVA). Secondary objectives included assessing the effects of therapy on vaginal atrophy, quality of life (QoL) and menopause-related symptoms.
Methods: 20 postmenopausal patients undergoing adjuvant letrozole therapy and experiencing VVA symptoms were treated with vaginal estradiol for 12 weeks.
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- The study examined the levels of serum estradiol (E2) and estrone (E1) in postmenopausal breast cancer patients undergoing letrozole treatment and investigated how these hormones relate to quality of life (QoL) and side effects.
- Out of 100 patients screened, 90 completed the trial, revealing that letrozole effectively suppressed E2 and E1 levels, while side effects like joint pain and muscle aches increased during treatment.
- The findings indicate that high baseline E2 levels were linked to increased joint and muscle pain, and highlight that traditional immunoassays are not effective for monitoring E2 during letrozole therapy due to sensitivity issues.
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