Effect of transcutaneous electrical acupoint stimulation in heart rate variability in post-on-call trainees.

Introduction: Anaesthesiology is a high-demand speciality with 24-hour on-call shifts, which can lead to significant stress and impaired sleep quality among anaesthetists. Nonpharmacological interventions like acupuncture have been widely explored for stress relief. This study aims to evaluate the impact of transcutaneous electrical acupoint stimulation (TEAS) on physiological parameters, specifically heart rate variability (HRV) and sleep quality, in anaesthesiology trainees following 24-hour on-call duty.

Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair.

The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as well as 3D rings and helical polymers, all implicated in mitigating plastid-associated membrane stress. The architecture of Vipp1 planar sheets and helical polymers remains unknown, as do the geometric changes required to transition between polymeric forms.

Nanoimprinting of Crosslinked Polyurethane / Polycaprolactone Blends: Scratch Recovery of Surface Topographies.

Scratch recovery of micro-nano-patterned polymer surfaces extends the service life of products that require tunable surface properties and contributes to more sustainable development. Scratch recovery has been widely studied in bulk and 4D-printed polymers via intrinsic self-healing mechanisms. Existing studies on self-healing of micro/nano-scale polymeric surfaces are limited to the recovery of controlled tensile or compressive strain.

Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.

Lactate is the highest turnover circulating metabolite in mammals. While traditionally viewed as a waste product, lactate is an important energy source for many organs, but first must be oxidized to pyruvate for entry into the tricarboxylic acid cycle (TCA cycle). This reaction is thought to occur in the cytosol, with pyruvate subsequently transported into mitochondria via the mitochondrial pyruvate carrier (MPC).