Publications by authors named "H Lindsey"
Article Synopsis
- A study found that changes in the brain entorhinal cortex (EC) and specific blood lipids are linked to Alzheimer's disease (AD) in individuals with the apolipoprotein E ε4 genetic variant.
- Analysis of brain imaging and lipid profiles revealed that ε4 carriers with mild traumatic brain injury (mTBI) had thicker left ECs, but repeated mTBIs reduced right EC thickness.
- The research highlights the need for further investigation into the relationship between ε4, mTBI, and specific blood lipid ratios as potential biomarkers for early detection of AD in affected individuals.
Importance: Blast-related mild traumatic brain injuries (TBIs), the "signature injury" of post-9/11 conflicts, are associated with clinically relevant, long-term cognitive, psychological, and behavioral dysfunction and disability; however, the underlying neural mechanisms remain unclear.
Objective: To investigate associations between a history of remote blast-related mild TBI and regional brain volume in a sample of US veterans and active duty service members.
Design, Setting, And Participants: Prospective cohort study of US veterans and active duty service members from the Long-Term Impact of Military-Relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC), which enrolled more than 1500 participants at 5 sites used in this analysis between 2014 and 2023.
Article Synopsis
- Neuroscience researchers are leveraging Big Data to improve the reliability of findings by increasing sample sizes and addressing replication issues.
- A study analyzed data from 53 studies with over 10,500 participants to connect scores from various auditory verbal learning tasks (AVLTs) while controlling for site-related effects.
- The research successfully reduced score variance by 37% and developed an online tool to help researchers and clinicians convert memory scores across different tests, highlighting the benefit of global data harmonization in behavioral sciences.
Article Synopsis
- Patients with active cancer or metastatic cancer are at a higher risk for acute cholecystitis, leading to increased complications and mortality when they receive surgical treatment.
- A study analyzed the treatment outcomes of 8,673 patients with acute cholecystitis, finding that those with cancer had a significantly higher 30-day mortality rate and higher chances of complications such as infectious issues.
- The findings suggest that cancer patients are often managed nonoperatively more than non-cancer patients, highlighting the need for tailored treatment approaches due to their distinct risk factors.
Article Synopsis
- The study aimed to investigate how rural and urban differences in caregiving, such as intensity, distance, burden, health, and support, vary across different U.S. Census regions (Northeast, South, Midwest, and West).
- It used data from 3,551 informal caregivers to older adults, collected from the National Health and Aging Trends Study, focusing on various outcome measures like caregiving intensity and caregiver health.
- Results showed that urban caregivers provided more assistance with daily activities, particularly in the Northeast and West, while caregivers in the South reported spending more hours caregiving each month.