Publications by authors named "H Lindhof"
Due to the global effects of climate change numerous infectious diseases are increasingly spreading to regions that were previously hardly or only slightly affected. As ocular involvement is possible in many of these infectious diseases, we must also adapt to new pathogens and clinical pictures in Germany in the medium to long term. Using selected bacterial, viral and mycotic pathogens and diseases as examples, the causes of the increase in dissemination and the consequences for ophthalmology are presented.
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- - Immune checkpoint inhibitors (ICIs) are important in cancer treatment but can cause immune-related adverse events (irAEs), with musculoskeletal issues being less common but impactful.
- - The mechanisms of these musculoskeletal irAEs are not well understood, and there are no clear treatment guidelines beyond using glucocorticosteroids.
- - In the case of a 72-year-old patient with severe ICI-induced polyarthritis unresponsive to glucocorticosteroids, treatment with the IL-17A/F/AF-inhibitor bimekizumab resulted in complete clinical and sonographic recovery.
[Hair growth with dupilumab in alopecia areata universalis and atopic dermatitis].
Dermatologie (Heidelb)
July 2022
We report the case of a 46-year-old woman who has suffered from severe atopic dermatitis since early childhood and from alopecia areata totalis since she was 18 years old, which has now developed into alopecia areata universalis. After the introduction of therapy with the monoclonal antibody dupilumab, renewed hair growth of the scalp, face and lower legs was observed. Dupilumab blocks the α‑subunit of interleukin (IL)-4 receptor and prevents the signaling cascade of IL‑4 and IL-13.
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