Publications by authors named "H Lester Kirchner"
Purpose: To assess trends in continuity of care (COC) by geographic context (i.e., rural vs urban) among a cohort of persons with prediabetes prior to and after diagnosis of prediabetes.
View Article and Find Full Text PDFBackground: Despite robust evidence supporting an association with improved outcomes in eligible patients, cardiac rehabilitation (CR) remains underused, with a minority of eligible patients participating. Virtual cardiac rehabilitation (VCR) has been proposed as an alternative to traditional center-based CR (CBCR) to improve usage rates. However, data supporting the efficacy and cost-effectiveness of VCR are limited.
View Article and Find Full Text PDFObjectives: This study aims to examine the relationship between left atrial appendage closure (LAAC) and post-operative atrial fibrillation (POAF) in cardiac surgery patients with no pre-operative atrial fibrillation (AF).
Methods: We analyzed a cohort of 2059 adult patients in our Society of Thoracic Surgery (STS) database who underwent at least one of the following procedures between 2018 and 2021: coronary artery bypass grafting (CABG), aortic valve replacement, or mitral valve replacement. All patients had no pre-operative AF, and 169 (8.
Article Synopsis
- Metabolic dysfunction-associated steatohepatitis (MASH) is linked to inflammation and fatty liver, and its progression may be influenced by reduced thyroid hormone signaling, specifically through decreased DIO1 and THRB expression.
- Research revealed that miR-34a-5p is increased in MASH patients and may play a role in suppressing thyroid hormone activity in the liver by targeting genes like THRB and DIO1.
- Additionally, DNA methylation changes in the THRB gene were found in MASH patients, potentially contributing to a state of resistance to thyroid hormones as the disease progresses.