Publications by authors named "H Lea"
Article Synopsis
- Scientists studied how men and women feel different temperatures to see if women really are colder than men.
- They found that women can feel cold at a lower temperature (about 21.9 °C) than men (about 22.9 °C) because women usually have more body fat for insulation.
- However, both men and women reacted similarly in other ways to cold, showing that body size and composition are the main reasons for feeling different temperatures, not just being a boy or a girl.
Article Synopsis
- This study investigates the dynamics of early immune responses to acute respiratory infections (ARIs), focusing on how an individual's immune system reacts before and after symptoms appear.
- Researchers used a self-sampling method to collect blood and nasal swabs from participants daily for a week and weekly afterward, analyzing samples to monitor immune gene activity and symptom development.
- A total of 68 participants contributed samples over the study period, with notable findings including that SARS-CoV-2 was detected in various participants, even when they showed no symptoms, offering insights into presymptomatic immune profiles.
Article Synopsis
- Blood transcriptional profiling is used to evaluate immune responses to infections, but traditional blood collection methods hinder accurate analysis during dynamic infections like COVID-19.
- A new at-home self-collection method allows participants to collect blood and nasal swabs every other day, enabling high-frequency measurement of immune response during acute SARS-CoV-2 infections.
- The study found significant differences in immune responses between healthy and COVID-19+ individuals, revealing distinct patterns based on vaccination status, and demonstrating the effectiveness of at-home sampling in tracking immune kinetics.
Lumen structures exist throughout the human body, and the vessels of the circulatory system are essential for carrying nutrients and oxygen and regulating inflammation. Vasodilation, the widening of the blood vessel lumen, is important to the immune response as it increases blood flow to a site of inflammation, raises local temperature, and enables optimal immune system function. A common method for studying vasodilation uses excised vessels from animals; major drawbacks include heterogeneity in vessel shape and size, time-consuming procedures, sacrificing animals, and differences between animal and human biology.
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