Publications by authors named "H Laumen"
Article Synopsis
- The DDOST protein is crucial for the N-linked glycosylation process in the endoplasmic reticulum and is linked to various cancers and congenital glycosylation disorders.
- Research shows that knocking down DDOST expression in pancreatic cancer cells (specifically PDAC) leads to changes in protein expression and interactions, pointing to its potential role in the disease.
- Results indicate that DDOST knockdown decreases cancer cell proliferation and viability while increasing stress responses and apoptosis, suggesting that DDOST may act as an oncogene and could be targeted for therapeutic strategies in pancreatic cancer.
Article Synopsis
- Genetic predisposition is significant for early-onset chronic pancreatitis (CP), with some cases linked to genetic changes in digestive enzyme genes, while others remain unexplained.
- Researchers investigated CTRL, a chymotrypsin-like protease, by screening over 1,000 CP patients and 1,500 controls for genetic variants, analyzing their effects on enzyme secretion and activity.
- Although several CTRL variants were identified, many did not impact function or were equally present in both patients and controls, suggesting that CTRL is probably not a major contributor to the development of CP.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal outcome. To improve understanding of sequential microbiome changes during PDAC development we analyzed mouse models of pancreatic carcinogenesis (KC mice recapitulating pre-invasive PanIN formation, as well as KPC mice recapitulating invasive PDAC) during early tumor development and subsequent tumor progression. Diversity and community composition were analyzed depending on genotype, age, and gender.
View Article and Find Full Text PDFBackground: Genetic alterations in digestive enzymes have been associated with chronic pancreatitis (CP). Recently, chymotrypsin like elastase 3B (CELA3B) emerged as a novel risk gene. Thus, we evaluated CELA3B in two European cohorts with CP.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the genetic factors of non-alcoholic chronic pancreatitis (NACP), focusing on the CUZD1 gene, which is highly expressed in pancreatic cells and may contribute to the disease's risk.
- - Researchers analyzed genetic data from thousands of patients and controls in Europe and Japan, finding several non-synonymous variants associated with NACP, especially in the European cohort.
- - The findings suggest CUZD1 could be a new susceptibility gene for NACP, but further research is needed to understand how these genetic variants lead to the development of pancreatitis.