Publications by authors named "H Langenfeld"
Clinical Presentation, Care Pathways, and Delays in Access to Specialized Care in Patients With Systemic Lupus Erythematosus: A Study From Lupus Midwest Network (LUMEN).
Arthritis Care Res (Hoboken)
October 2024
Objective: We aimed to characterize presentation and care pathways of patients with systemic lupus erythematosus (SLE), and delays in access to SLE-specialized care.
Methods: We included patients with incident SLE from the Lupus Midwest Network registry. Time from the first medical encounter for SLE clinical manifestation to access to SLE-specialized care, physician diagnosis, and treatment was estimated.
Objectives: To examine the clinicopathologic features of patients with polymyalgia rheumatica (PMR) who had thoracic aorta repair surgery. Findings were compared with those of a cohort of patients with giant cell arteritis (GCA) requiring thoracic aorta repair.
Methods: All patients evaluated at Mayo Clinic in Rochester, MN, with Current Procedural Terminology (CPT) codes for thoracic aorta repair surgery between 2000- 2021 were identified.
Article Synopsis
- Adrenal hemorrhage (AH) is a serious condition linked to antiphospholipid Syndrome (APS), affecting primarily middle-aged adults, and leading to complications like primary adrenal insufficiency and increased mortality rates.
- A study analyzed 256 patients with APS-AH, finding that 69% had bilateral adrenal involvement and common symptoms included abdominal pain, nausea, and vomiting, with hyponatremia as the prevalent electrolyte disorder.
- The five-year survival rate was 82%, but a history of stroke significantly increased the risk of mortality, highlighting the need for careful monitoring and treatment strategies in affected patients.
Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review.
Clin Immunol
November 2023
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disease linked to blood clots and pregnancy complications, with severe cases sometimes causing diffuse alveolar hemorrhage (DAH).
- A study analyzed data from 219 patients with APS-associated DAH to identify clinical features, treatments, and factors affecting patient outcomes, using various statistical methods for assessment.
- Findings showed a high relapse rate (47% at six months) and significant mortality rates (30.3% at one year), with severe thrombocytopenia, valve vegetations, and catastrophic APS being linked to higher mortality risk.
Objectives: ANCA-associated vasculitis (AAV) is currently categorized under the small vessel vasculitides. There is limited knowledge about large vessel involvement in AAV (L-AAV), mainly described in case reports and small series. L-AAV can involve temporal arteries (TA-AAV), aorta (A-AAV), and periaortic soft tissue (PA-AAV).
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