Exploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids.

Background: Recent research indicates a role of gut microbiota in development and progression of life-threatening diseases such as cancer. Carcinomas of the biliary ducts, the so-called cholangiocarcinomas, are known for their aggressive tumor biology, implying poor prognosis of affected patients. An impact of the gut microbiota on cholangiocarcinoma development and progression is plausible due to the enterohepatic circulation and is therefore the subject of scientific debate, however evidence is still lacking.

Psychological stress and depression symptoms in nursing undergraduates: the chain mediating effect of cognitive reappraisal and ruminate thinking.

Background: Nursing students exhibit a higher incidence of mental disorders. Studies have identified psychological stress contributes to elevated depression symptoms through reappraisal cognitive in nursing students. However, there is little research exploring the knowledge regarding the role of ruminative thinking in mediating the associations between psychological stress and depression symptoms.

Organoids in skin wound healing.

Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs . Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various environments.

The effect of tumor downsizing on surgical complexity during nephrectomy after immune checkpoint inhibitors for metastatic renal cell carcinoma.

Purpose: Immune Checkpoints Inhibitors (ICI) have changed the therapeutic landscape of metastatic renal cell carcinoma first-line treatment with complete response (CR) at metastatic sites observed in 10 to 15% of cases. Delayed nephrectomy could be discussed for patients having a clinical benefit from immunotherapy-based treatment. However, it is unclear whether prior immunotherapy exposure adversely influences the complexity of surgery.

Construction of an Index System of the Biosafety Incident Response Capability for Nursing Staff: A Delphi Study.

Aim: This study was to establish a scientific and sensitive index system of the biosafety incident response competence for clinical nursing staff to provide a reference for the evaluation of nurses' biosafety incident response competence.

Design: A modified recommendation for the conducting and reporting of Delphi studies was used to guide this study.

Methods: According to the literature review, preliminary biosafety incident response competence indicators for nursing staff were established, and an expert survey questionnaire was designed.