Photobiocatalytic CO reduction into CO by organic nanorod-carbon monoxide dehydrogenase assemblies: surfactant matters.

Photobiocatalytic CO reduction represents an attractive approach for conversion of solar light and abundant resources to value-added chemicals. However, the design of suitable systems requires a detailed understanding of the interaction between the artificial photosensitizer and biocatalyst interface. In this work, we investigate the effect of surfactant charge utilized in the preparation of a phenoxazine-based organic molecule nanorod photosensitizer on the interaction with the carbon monoxide dehydrogenase II from within biohybrid assemblies for sacrificially driven photobiocatalytic CO reduction into CO.

Secondary structure changes as the potential H sensing mechanism of group D [FeFe]-hydrogenases.

[FeFe]-hydrogenases function as both H catalysts and sensors. While catalysis is well investigated, details regarding the H sensing mechanism are limited. Here, we relate protein structure changes to H sensing, similar to light-driven bio-sensors.

Exon-Skipping-Based Subtyping of Colorectal Cancers.

Background & Aims: The identification of colorectal cancer (CRC) molecular subtypes has prognostic and potentially diagnostic value for patients, yet reliable subtyping remains unavailable in the clinic. The current consensus molecular subtype (CMS) classification in CRCs is based on complex RNA expression patterns quantified at the gene level. The clinical application of these methods, however, is challenging due to high uncertainty of single-sample classification and associated costs.