Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma.

Background And Aims: Immune checkpoint inhibitors (ICIs) have revolutionized systemic hepatocellular carcinoma (HCC) treatment. Nevertheless, numerous patients are refractory to ICIs therapy. It is currently unknown whether diet therapies such as short-term starvation (STS) combined with ICIs can be used to treat HCC.

Prediction of rain garden runoff control effects based on multiple machine learning techniques.

Due to the rapid development of urbanisation, cities frequently experience waterlogging during rainfall. Rain gardens are widely used in new urban construction because they effectively control surface runoff from rainwater, thereby reducing waterlogging. The runoff control effectiveness of rain gardens is influenced by multiple factors.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

Programmable Stapling Peptide Based on Sulfonium as Universal Vaccine Adjuvants for Multiple Types of Vaccines.

Adjuvants are non-specific immune enhancers commonly used to improve the responsiveness and persistence of the immune system toward antigens. However, due to the undefined chemical structure, toxicity, non-biodegradability, and lack of design technology in many existing adjuvants, it remains difficult to achieve substantive breakthroughs in the adjuvant research field. Here, a novel adjuvant development strategy based on stapling peptides is reported to overcome this challenge.

Exploring orthogonally dual-polarization nonplanar circular modes in solid-state lasers: experimental generation and theoretical representation.

A transversely isotropic diode-pumped solid-state laser is used to obtain an orthogonally dual-polarization nonplanar circular mode (NCM) under off-axis pumping in the strictly degenerate cavity. Each polarized component of the NCM outside the cavity is revealed to be individually localized on the ray orbits forming a nonplanar surface, in which the transverse patterns display multiple spots well positioned on a circular structure. An analytical representation is established to explore polarization-resolved components of the NCM by utilizing the Gaussian wave packet to directly correlate with geometrical rays.