Publications by authors named "H L Thacker"
Health system resilience refers to the capacity of a health system to effectively anticipate, assimilate, adjust to and recuperate from unforeseen disruptions and pressures. Evidence indicates that low- and middle-income countries (LMICs) have a double burden of dealing with the existing shortage of health resources in managing both non-emergency care and emergency care during epidemics. Intersectoral collaboration plays a pivotal role in managing crises such as pandemics.
View Article and Find Full Text PDFBackground: Systemic Lupus Erythematosus (SLE) is characterized by dysregulated immune responses, with neutrophil extracellular traps (NETs) playing a significant role. NETs are recognized by autoantibodies in SLE patients, exacerbating pathology. Both excessive NET formation and impaired degradation contribute to SLE pathophysiology.
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- Neutrophil extracellular traps (NETs) play a crucial role in the immune response, but the processes behind their formation, known as NETosis, are not fully understood.
- This study investigates the downregulation of two G-protein coupled receptors, C5aR1 and LTB4R1, in neutrophils from low birth weight newborns and how they affect NET formation.
- Using various laboratory techniques, researchers confirmed that inhibiting these receptors reduced extracellular DNA release and proteins associated with NETs, highlighting their importance in the regulation of NETosis.
Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been used for almost a decade and have proven to be effective not only in managing Type 2 diabetes (T2D), but their cardio and renal protective features make them very useful in managing patients with risk of multiple comorbidities. This systematic review was undertaken by the authors because there is no evidence currently available in India that has studied the suitability of SGLT2i as a first-line agent in patients newly diagnosed with T2D in India.
Materials And Methods: First, literature was searched to identify features that are considered important when deciding on a first-line agent for managing T2D.
Background: Work-related musculoskeletal disorders (WMSDs) are the second most common cause of disability, accounting for 17% of all Years lived with a disability (YLDs) worldwide. Healthcare professionals, especially dentists, are known to be at a higher risk of WMSDs. Therefore, this study aims to determine the point and period prevalence of WMSDs among dentists and to assess the risk factors for WMSDs, including workstation analysis.
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