Breaking the Ice: Hofmeister Effect-Inspired Hydrogen Bond Network Reconstruction in Hydrogel Electrolytes for High-Performance Zinc-Ion Batteries.

Gel electrolytes have emerged as a promising solution for enhancing the performance of zinc-ion batteries (ZIBs), particularly in flexible devices. However, they face challenges such as low-temperature inefficiency, constrained ionic conductivity, and poor mechanical strength. To address these issues, this study presents a novel PAMCD gel electrolyte with tunable freezing point and mechanical properties for ZIBs, blending the high ionic conductivity of polyacrylamide with the anion interaction capability of β-cyclodextrin.

Total laparoscopic closed reduction and internal fixation for AO/OTA B2.1 pelvic fracture: A case report and literature review.

Endoscopic techniques have been widely used in orthopedic surgery, such as arthroscopy and transforaminal endoscopy, but the application in fracture is rarely reported. We reported a case of a 69-year-old male with pelvic fracture (AO/OTA type B2.1) who underwent successful laparoscopy-assisted pubic ramus plate fixation without auxiliary incision.

Engineering and construction of multi-functional Janus separator for high-stability Li-CO battery.

Due to the high theoretical energy density, lithium-carbon dioxide (Li-CO) batteries provide unique advantages when using CO to generate electricity. However, the issues with lithium dendrite generated by uneven deposition and quick cathode passivation continue to impede the development of Li-CO batteries. In this work, a Janus separator with dual functionalities is created using an in-situ growth and hydrothermal technique.

SALL4 mediates SHP2 inhibition in myocardial fibroblasts through the DOT1L/H3K79me2 signaling pathway to promote the progression of myocardial infarction.

Objective: To explore the influence of SALL4 in cardiac fibroblasts on the progression of myocardial infarction.

Methods: Analysis of genes specifically expressed in myocardial infarction by bioinformatics methods; The impact of SALL4 on myocardial infarction was assessed using mouse ultrasound experiments and Masson staining; The effect of SALL4 on the expression levels of collagen-I and collagen-III in myocardial tissue was examined by immunohistochemical staining; The migration ability of cardiac fibroblasts was evaluated using a Transwell assay; The proliferative ability of cardiac fibroblasts was tested using a CCK-8 assay; The relative fluorescence intensity of α-SMA and CTGF in cardiac fibroblasts were checked through immunofluorescence staining experiment; The expression of SALL4, DOT1L, H3K79me2, P53, SHP2, YAP, nucleus-YAP, collagen-I, α-SMA, CTGF, and PAI-1 in myocardial tissues or cardiac fibroblasts was detected using western blot analysis.

Results: SALL4-specific high expression in myocardial infarction; SALL4 intensified the alterations in the heart structure of mice with myocardial infarction and worsened the fibrosis of myocardial infarction; SALL4 also promoted the expression of SALL4, DOT1L, H3K79me2, P53, SHP2, YAP, nucleus-YAP, collagen-I, collagen-III, α-SMA, CTGF, and PAI-1 in myocardial infarction tissues and cardiac fibroblasts; Subsequently, SALL4 could enhance the immunofluorescence intensity of α-SMA and CTGF; Moreover, SALL4 could promote the proliferation and migration of cardiac fibroblasts.

Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways.

Depleted uranium (DU) is a byproduct of uranium enrichment, which can cause heavy-metal toxicity and radiation toxicity as well as serious damage to the kidneys. However, the mechanism of renal injury induced by DU is still unclear. This study aimed to explore the role of ethylmalonic encephalopathy 1 (ETHE1) in DU-induced mitochondrial dysfunction and elucidate the underlying mechanisms.