Publications by authors named "H L RAKOV"
Cathepsin K deficiency in male mice (Ctsk) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland where it contributes to the liberation of thyroid hormones (TH). Because TH are essential for brain development, in particular for the cerebellum, we investigated whether cathepsin K's function in the thyroid is directly linked to the brain phenotype of Ctsk mice.
View Article and Find Full Text PDFSerum thyroid state in older adults correlates with extended longevity. We hypothesized that age impacts not only systemic but also organ-specific thyroid state and response to thyroxine (T4). Young (3 months) and old (23 months) male mice were analyzed at baseline and after acute T4 challenge.
View Article and Find Full Text PDFClinical manifestation of hyperthyroidism and hypothyroidism vary with age, with an attenuated, oligosymptomatic presentation of thyroid dysfunction (TD) in older patients. We asked, whether in rodents TD phenotypes are influenced by age and whether this involves changes in systemic and/or organ thyroid hormone (TH) signaling. Chronic hyper- or hypothyroidism was induced in male mice at different life stages (5, 12, and 20 months).
View Article and Find Full Text PDFBackground: Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked whether sex impacts the phenotypes of hyper- and hypothyroidism at two life stages.
Methods: Hyper- and hypothyroidism were induced by i.
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
Proc Natl Acad Sci U S A
December 2017
Article Synopsis
- - Thyroid hormone (TH) and its receptors (TRs) can act through two pathways: the traditional type 1 pathway involves gene expression by binding to DNA, while a nontraditional type 3 pathway activates other cellular processes quickly without affecting gene expression.
- - Researchers created mutant mice that cannot bind DNA via TRs, which helped them discover that key physiological effects of TH, like heart rate and blood sugar levels, can still occur through the noncanonical signaling pathway.
- - The study demonstrates that noncanonical TR signaling has significant effects on metabolism and heart function, suggesting that thyroid hormone's actions are more complex than previously believed and not solely dependent on altering gene transcription.