Publications by authors named "H L Pilmore"
Background: Recurrent glomerulonephritis (GN) is an important cause of allograft loss after transplantation when GN is the primary cause of kidney failure. Retransplantation after allograft loss from recurrent disease requires careful consideration. We aimed to determine the probability of relisting and the risk of allograft loss after retransplantation in recipients with prior allograft loss from recurrent GN.
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- * Researchers analyzed data from 642 allograft failures, finding that various forms of rejection accounted for the majority (47.5%) of cases, with chronic antibody-mediated rejection being the most common cause.
- * The findings suggest a need for better strategies to manage immune responses and more research on less understood causes of kidney transplant failure, particularly undifferentiated interstitial fibrosis and tubular atrophy.
Background: Mycophenolate dose reduction (MDR) is associated with acute rejection and transplant failure in kidney transplant recipients (KTRs). The optimal dose to prevent rejection and reduce complications remains poorly defined in tacrolimus-based regimens.
Methods: We assessed adult KTRs from 2005 to 2017 initiated on mycophenolate mofetil 2 g/d, tacrolimus, and prednisolone from the Australia and New Zealand Dialysis and Transplant Registry.
Article Synopsis
- - The study explores mortality risks in male vs female heart transplant recipients to inform better management strategies based on sex, focusing on the excess risk above the general population.
- - Analyzing data from 108,918 patients from 1988 to 2019, results showed female recipients generally had higher excess mortality risks compared to male recipients, particularly when the donor was male.
- - Conclusions suggest that while females had higher mortality risks across all ages with male donors, only females aged 13-44 had a non-significant increase in risk with female donors, indicating a need for further research into these gender differences.
Background: Diabetes mellitus (DM) is associated with a greater risk of mortality in kidney transplant patients, primarily driven by a greater risk of cardiovascular disease (CVD)-related mortality. However, the associations between diabetes status at time of first allograft loss and mortality on dialysis remain unknown.
Methods: All patients with failed first kidney allografts transplanted in Australia and New Zealand between 2000 and 2020 were included.