Publications by authors named "H L Penny"
Background And Aims: In coeliac disease, the clinical role of the urinary gluten immunogenic peptide is unclear. It has been suggested it can be a non-invasive marker of villous atrophy. Therefore, we present the largest cross-sectional clinical data in patients with coeliac disease to establish the diagnostic accuracy of the urinary gluten immunogenic peptide in identifying villous atrophy.
View Article and Find Full Text PDFOptimising the Diagnosis of Adult Coeliac Disease: Current Evidence and Future Directions.
Br J Hosp Med (Lond)
September 2024
Coeliac disease is a common autoimmune disorder that affects nearly 1% of the general population. Current diagnostic strategies involve active case finding, serological tests, and endoscopy with biopsies. However, many patients with coeliac disease remain undiagnosed due to a wide gap between clinical guidelines and real-world practice in the diagnosis of adult coeliac disease.
View Article and Find Full Text PDFArticle Synopsis
- - Parents of children with skin conditions often experience high levels of stress, and current psychological support for these families is limited.
- - The 'Living in the Present' mindfulness program was tested on ten parents to see if it could lower stress levels and improve the quality of life for both parents and their children.
- - Results showed mixed improvements in stress and quality of life, with some participants benefiting while others struggled with anxiety, indicating the need for more thorough research on such interventions.
Patient preferences for the diagnosis of coeliac disease: A discrete choice experiment.
United European Gastroenterol J
August 2024
Background: There is potential for a paradigm shift from a biopsy-to a serology-based diagnosis of coeliac disease in selected adult patients. However, it remains unknown if this approach would be acceptable to patients. We aimed to explore patients' preferences regarding the no-biopsy approach for coeliac disease diagnosis.
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- Potential coeliac disease (PCD) is defined by positive tests for coeliac disease while maintaining normal intestinal tissue structure, with uncertainty about its progression to full-blown coeliac disease.
- A systematic review of 17 studies involving 1,010 patients found that approximately 33% developed villous atrophy or normalized their serology while on a gluten-containing diet.
- Nearly 88% of patients adhering to a gluten-free diet experienced symptom relief, emphasizing the need for careful monitoring and personalized treatment plans for those with PCD.