Publications by authors named "H L Newmark"
In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and for what purpose is not obvious.
View Article and Find Full Text PDFThe pharmacokinetic disposition of a dietary cancer chemopreventive compound dibenzoylmethane (DBM) was studied in male Sprague-Dawley rats after intravenous (i.v.) and oral (p.
View Article and Find Full Text PDFThe biological activities of tocotrienols are receiving increasing attention. Herein, we report the efficacy of a mixed-tocotrienol diet against prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) mouse model. Male TRAMP mice, 8 wk old, were fed 0.
View Article and Find Full Text PDFIncreased calcium intake from dairy products has been suggested as a risk factor for prostate cancer. We propose that the high dietary phosphate of dairy products may more readily explain this risk rather than the increased calcium. Several epidemiologic correlations have indicated an increased risk of prostate cancer with long-term, high intake of dairy products in male U.
View Article and Find Full Text PDFArticle Synopsis
- Dibenzoylmethane (DBM) is a compound found in licorice that shows promise in fighting prostate cancer by inducing cell cycle arrest and regulating androgen receptor activity.
- In laboratory studies with TRAMP-C1 cells and TRAMP mice, DBM effectively halted cell growth in a specific phase of the cell cycle and reduced various cancer-related proteins.
- Mice fed a diet with DBM exhibited a lower incidence of tumors and advanced precancerous lesions, suggesting that DBM could be a potential candidate for future prostate cancer treatments.