Diverged Populations Admixture Bolsters Genetic Diversity of a New Island Dibbler () Population, but Does Not Prevent Subsequent Loss of Genetic Variation.

Translocating individuals from multiple source populations is one way to bolster genetic variation and avoid inbreeding in newly established populations. However, mixing isolated populations, especially from islands, can potentially lead to outbreeding depression and/or assortative mating, which may limit interbreeding between source populations. Here, we investigated genetic consequences of mixing individuals from two island populations of the dibbler () in an island translocation.

Long-term incidence of implantable cardioverter-defibrillator therapy in patients with hypertrophic cardiomyopathy: analysis of appropriate and inappropriate interventions.

Background: Treatment with implantable cardioverter-defibrillators (ICDs) effectively prevents sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). Identifying patients most likely to benefit from a primary prevention ICD remains challenging. We aimed to investigate the long-term incidence of ICD therapy in patients with HCM according to SCD-risk at baseline.

Traumatic Brain Injury and Risk of Incident Comorbidities.

Importance: Traumatic brain injury (TBI) is associated with chronic medical conditions. Evidence from diverse clinical administrative datasets may improve care delivery.

Objective: To characterize post-TBI risk of incident neuropsychiatric and medical conditions in a California health care system administrative database and validate findings from a Massachusetts dataset.

Clinical Assessment and Factors Influencing Treatment Strategy and Outcomes in Complex Limb Injuries.

Complex limb injuries are high-energy injuries that may threaten limb viability and confer significant morbidity and mortality. Prompt clinical assessment and decision-making are critical to determining the optimal management strategy, i.e.

Locally Delivered Antibiotics in Fracture-Related Infection.

The prevention and treatment of fracture-related infections (FRIs) pose significant challenges in orthopaedic trauma care, with current practices predominantly relying on systemic antibiotic administration. However, locally delivered antibiotics achieve substantially higher tissue concentrations and minimise systemic side effects. Whilst extensively researched in periprosthetic joint infections (PJIs), the use of local delivery methods is increasingly prevalent in FRI prevention and treatment.