Publications by authors named "H L Levin"
Article Synopsis
- HIV-1 integration primarily occurs in actively transcribed genes, influenced by the interaction of the viral integrase with the host chromatin factor LEDGF.
- LEDGF is found enriched at the transcription start sites of active genes and plays a significant role in recruiting RNA Pol II, indicating its involvement in enhancing transcription.
- The study suggests a dual role for LEDGF, where it is initially anchored to gene promoters through MLL1 and then facilitates HIV-1 integration across gene bodies, with implications for understanding specific leukemia types related to LEDGF function.
Intensive Care Med
July 2024
Article Synopsis
- The study aimed to use standardized and automated CT assessments to predict outcomes for patients who suffered out-of-hospital cardiac arrest.
- Involving 140 unconscious patients, results showed that while qualitative assessments and various gray-white-matter ratio (GWR) models achieved 100% specificity in predicting poor outcomes, sensitivity rates varied, with automated GWR proving robust.
- The research concluded that these CT assessment methods could reliably indicate poor functional outcomes, and automated GWR could enhance accessibility for medical centers handling cardiac arrest cases.
Article Synopsis
- - The study aimed to assess the effectiveness of glial fibrillary acidic protein (GFAP) and total-tau in predicting neurological outcomes in patients who suffered cardiac arrest, comparing these biomarkers with neurofilament light (NFL) and neuron-specific enolase (NSE).
- - Conducted in three Swedish hospitals between 2014 and 2018, researchers examined blood samples from 428 cardiac arrest patients at various times post-arrest, finding that GFAP was a strong predictor of poor neurological outcomes at multiple time points.
- - Results indicated that while GFAP and tau show promise as biomarkers, NFL demonstrated equal or superior predictive capabilities compared to GFAP and tau after both out-of-hospital and in-hospital cardiac arrests. Additionally
Intensive Care Med
January 2024
Article Synopsis
- The study evaluated the effectiveness of highly malignant EEG patterns (HMEP) in predicting poor neurological outcomes after cardiac arrest, following 2021 guidelines from the ERC and ESICM.
- In a multicenter trial involving 845 patients, HMEP showed 50% sensitivity and 93% specificity for poor outcomes, with an increase in specificity to 97% when combined with an unresponsive EEG.
- The findings indicate that while the specificity of these EEG patterns is high, it's less than previously reported, suggesting a need for cautious application in clinical settings due to potential biases affecting results.
