Publications by authors named "H L Kirchner"
Background: Despite robust evidence supporting an association with improved outcomes in eligible patients, cardiac rehabilitation (CR) remains underused, with a minority of eligible patients participating. Virtual cardiac rehabilitation (VCR) has been proposed as an alternative to traditional center-based CR (CBCR) to improve usage rates. However, data supporting the efficacy and cost-effectiveness of VCR are limited.
View Article and Find Full Text PDFBackground: Our knowledge of X-linked Alport Syndrome comes mostly from selected cohorts with more severe disease.
Methods: We examined the phenotypic spectrum of X-linked Alport Syndrome in males and females with a genotype-based approach using data from the Geisinger MyCode DiscovEHR study, an unselected health system-based cohort with exome sequencing and electronic health records. Patients with COL4A5 variants reported as pathogenic or likely pathogenic in ClinVar, or protein-truncating variants, were each matched with up to 5 controls without COL4A3/4/5 variants by sociodemographics, diabetes diagnosis, and year of first outpatient encounter.
Objectives: This study aims to examine the relationship between left atrial appendage closure (LAAC) and post-operative atrial fibrillation (POAF) in cardiac surgery patients with no pre-operative atrial fibrillation (AF).
Methods: We analyzed a cohort of 2059 adult patients in our Society of Thoracic Surgery (STS) database who underwent at least one of the following procedures between 2018 and 2021: coronary artery bypass grafting (CABG), aortic valve replacement, or mitral valve replacement. All patients had no pre-operative AF, and 169 (8.
Article Synopsis
- Metabolic dysfunction-associated steatohepatitis (MASH) is linked to inflammation and fatty liver, and its progression may be influenced by reduced thyroid hormone signaling, specifically through decreased DIO1 and THRB expression.
- Research revealed that miR-34a-5p is increased in MASH patients and may play a role in suppressing thyroid hormone activity in the liver by targeting genes like THRB and DIO1.
- Additionally, DNA methylation changes in the THRB gene were found in MASH patients, potentially contributing to a state of resistance to thyroid hormones as the disease progresses.
Study Objectives: To examine the association between moderate-severe obstructive sleep apnea (msOSA) and sleep characteristics with chronic kidney disease (CKD) in a population of rural and urban adults in Pennsylvania.
Methods: A cross-sectional study of 23,643 adults who underwent polysomnography (PSG) at a rural healthcare system in Pennsylvania between 2009 and 2019. Serum creatinine was abstracted from electronic health records to calculate estimated glomerular filtration rate (eGFR).